CAZy: Carbohydrate-Active Enzymes Database.

На сайте представлена современная классификация ферментов синтеза и утилизации углеводов, а также их гомологов. Ферменты (а точнее каждый из их модулей/доменов) разбиты на пять групп: Glycosidases and Transglycosidases, Glycosyltransferases, Polysaccharide Lyases, Carbohydrate Esterases, Carbohydrate-Binding Modules. В пределах каждого из них выделяются семейства, которые нумеруются арабскими цифрами в порядке описания. Каждое семейство объединяет "хорошие" гомологи. Родственные семейства объединены в кланы. Например, гликозидазы и трансгликозидазы образуют 113 семейств (GH1-GH118, кроме GH21, GH40, GH41, GH60 и GH69). Из них 50 семейств объединены в 14 кланов (GH-A–GH-N). Информация о каждом из семейств включает список его представителей из разных организмов с ссылками на базы данных аминокислотных и нуклеотидных последовательностей, указание ферментативных активностей, названий белков, наличия экспериментально определённых трёхмерных структур, данные о молекулярном механизме катализируемой реакции и компонентах активного центра. База данных обновляется примерно раз в месяц.

Ссылки на статьи с описанием классификации:
1. Biochemical Journal, 1991
2. Biochemical Journal, 1993
3. Biochemical Journal, 1996
4. Biochemical Journal, 1997
5. Recent Advances in Carbohydrate Bioengineering, 1999
6. Nucleic Acids Research, 2009

Glycosidases and Transglycosidases.

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В развитие двухуровневой (семейство/клан) классификации каталитических доменов гликозил-гидролаз и их гомологов предложена многоуровневая иерархическая классификация:

Naumoff D.G. Development of a hierarchical classification of the TIM-barrel type glycoside hydrolases. // Proceedings of the Fifth International Conference on Bioinformatics of Genome Regulation and Structure. July 16-22, 2006. Novosibirsk. Russia. V.1. P.294-298. PDF

На ряду с Carbohydrate-Active Enzymes Database теперь ещё существует и CAZypedia.

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